In the day's early kick-off, holders Chelsea were knocked out of the competition after losing their fourth-round replay against Everton on penalties.
After a goalless 90 minutes at Stamford Bridge, Frank Lampard gave the holders the lead in the first-half of extra-time before Leighton Baines curled home a superb 25-yard free-kick in the last minute to take the match to a shootout.
Baines then saw his spot-kick - Everton's first - saved by Petr Cech, but Nicolas Anelka's effort was superbly saved by Tim Howard before Ashley Cole fired Chelsea's fifth penalty over the bar to allow Phil Neville to seal a 4-3 shootout win.
Everton will now face Reading at Goodison Park in their fifth-round match on Tuesday 1st March.
COMFORTABLE VICTORY
In Saturday's fifth round matches, Birmingham City and Stoke City successfully navigated their way past lower league opposition, with each team enjoying a 3-0 win.
Birmingham cruised into the quarter-finals of the FA Cup for the second successive season after their win over Sheffield Wednesday  - but Alexander Hleb could be facing Wembley heartbreak.
Hleb set up the first two goals for Jean Beausejour and Obafemi Martins but was then stretchered off and looks doubtful for next weekend's Carling Cup final with his former club Arsenal.
Full-back David Murphy scored the third goal early in the second period and Birmingham were comfortable winners despite making eight changes.
Meanwhile, Stoke sealed their place in the sixth round with a comfortable victory over Brighton and Hove Albion at the Britannia Stadium.
The visitors were undone by three first-half headers, with John Carew netting after 14 minutes and his strike partner Jon Walters making it 2-0 eight minutes later.
Walters then set up Potters captain Ryan Shawcross just before the interval, and although Brighton improved in the second period, they were unable to reduce the deficit.
Finally, Richard Brodie hit the bar in stoppage time as non-league Crawley Town narrowly failed to take Manchester United to an FA Cup replay.
Wes Brown's first-half header proved enough for United, who struggled to cope with Crawley's tenacity.